57,487 research outputs found

    Participation in college sports and protection from sexual victimization

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    Some sociologists have argued that sport is a male-dominated institution and sexist culture in which female athletes experience various forms of discrimination, including sexual harassment from coaches and male athletes. Some research does indicate that female athletes suffer higher rates of sexual victimization from authority figures in sport than their nonathletic counterparts in education and the workplace. In contrast, researchers have also speculated that athletic participation can protect female athletes from sexual victimization through a variety of social-psychological mechanisms such as team membership, physical strength, and self-confidence. This paper reports on the first descriptive analysis to test the “sport protection hypothesis” among both female and male athletes, using cross-tabulation secondary analyses of data from the National College Health Risk Behavior Survey, conducted in 1995 by the U.S. Centers for Disease Control and Prevention (N=4814). USA college students of traditional undergraduate age (aged 18-24) were included in the sample (N=2903). Some limited support for the protection hypothesis was found, and student athletes were significantly less likely to report sexual victimization during their late high school and early college years than their nonathletic counterparts. A gender gap in the pattern of sexual victimization also appeared between males and females across all student age groups, with females experiencing more sexual victimization than males. However, no significant gender gap was found among athletes. The results are discussed in relation to previous studies of campus athletes and to college prevention policy

    RNA-seq transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis

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    Bovine tuberculosis, caused by infection with Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries. The development of high-throughput functional genomics technologies, including gene expression microarrays and RNA-sequencing (RNA-seq), has enabled detailed analysis of the host transcriptome to M. bovis infection, particularly at the macrophage and peripheral blood level. In the present study, we have analyzed the peripheral blood leukocyte (PBL) transcriptome of eight natural M. bovis-infected and eight age- and sex-matched non-infected control Holstein-Friesian animals using RNA-seq. In addition, we compared gene expression profiles generated using RNA-seq with those previously generated using the high-density Affymetrix(®) GeneChip(®) Bovine Genome Array platform from the same PBL-extracted RNA. A total of 3,250 differentially expressed (DE) annotated genes were detected in the M. bovis-infected samples relative to the controls (adjusted P-value ≤0.05), with the number of genes displaying decreased relative expression (1,671) exceeding those with increased relative expression (1,579). Ingenuity(®) Systems Pathway Analysis (IPA) of all DE genes revealed enrichment for genes with immune function. Notably, transcriptional suppression was observed among several of the top-ranking canonical pathways including Leukocyte Extravasation Signaling. Comparative platform analysis demonstrated that RNA-seq detected a larger number of annotated DE genes (3,250) relative to the microarray (1,398), of which 917 genes were common to both technologies and displayed the same direction of expression. Finally, we show that RNA-seq had an increased dynamic range compared to the microarray for estimating differential gene expression

    Research on Optimized Problem-solving Solutions: Selection of the Production Process

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    In manufacturing industries, various problems may occur during the production process. The problems are complexand involve the relevant context of working environments. A problem-solving process is often initiated to create asolution and achieve a desired status. In this process, determining how to obtain a solution from the variouscandidate solutions is an important issue. In such uncertain working environments, context information can providerich clues for problem-solving decision making. This work uses a selection approach to determine an optimizedproblem-solving process which will assist workers in choosing reasonable solutions. A context-based utility modelexplores the problem context information to obtain candidate solution actual utility values; a multi-criteria decisionanalysis uses the actual utility values to determine the optimal selection order for candidate solutions. Theselection order is presented to the worker as an adaptive knowledge recommendation. The worker chooses areasonable problem-solving solution based on the selection order. This paper uses a high-tech company’sknowledge base log as a source of analysis data. The experimental results show that the chosen approach to anoptimized problem-solving solution selection is effective. The contribution of this research is a method which iseasy to implement in a problem-solving decision support system

    Putting context into organizational intervention design:Using tailored questionnaires to measure initiatives for worker well-being

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    Realistic evaluation emphasizes the importance of exploring the mechanisms through which organizational interventions are effected. A well-known mechanism in organizational interventions is the screening process. Standardized questionnaires, in popular use, neither consider individuals’ appraisals of working conditions nor the specific context of the workplace. Screening with items tailored to intervention contexts may overcome the limitations of standardized questionnaires. In the present study, we evaluate an approach to develop a tailored questionnaire to measure employees’ appraisals of their specific working conditions. First, we interviewed 56 employees and 17 managers and, later, developed tailored items focused on the working conditions in a postal service. In follow-up interviews, we explore participants’ experiences with the tailored questionnaire, including the development of initiatives, compared to their previous experiences with the company´s annual attitude survey that used standardized scales. Results indicated that participants felt the tailored questionnaire highlighted issues that had previously been ignored, that initiatives were easier to develop due to its specificity, and that the feedback strategy was useful in prioritizing questionnaires. Overall, it can be concluded that tailored questionnaires may be appropriate for use in organizational intervention research and more broadly that evaluations of organizational interventions need to be contextually grounded

    Oxygen-vacancy-mediated Negative Differential Resistance in La and Mg co-substituted BiFeO3 Thin Film

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    The conductive characteristics of Bi0.9La0.1Fe0.96Mg0.04O3(BLFM) thin film are investigated at various temperatures and a negative differential resistance (NDR) is observed in the thin film, where a leakage current peak occurs upon application of a downward electric field above 80 oC. The origin of the NDR behavior is shown to be related to the ionic defect of oxygen vacancies (VO..) present in the film. On the basis of analyzing the leakage mechanism and surface potential behavior, the NDR behavior can be understood by considering the competition between the polarized distribution and neutralization of VO..

    Mechanism for current saturation and energy dissipation in graphene transistors

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    From a combination of careful and detailed theoretical and experimental studies, we demonstrate that the Boltzmann theory including all scattering mechanisms gives an excellent account, with no adjustable parameters, of high electric field transport in single as well as double-oxide graphene transistors. We further show unambiguously that scattering from the substrate and superstrate surface optical (SO) phonons governs the high field transport and heat dissipation over a wide range of experimentally relevant parameters. Models that neglect SO phonons altogether or treat them in a simple phenomenological manner are inadequate. We outline possible strategies for achieving higher current and complete saturation in graphene devices.Comment: revtex, 5 pages, 3 figures, to appear in Phys. Rev. Lett

    Comparative functional genomics and the bovine macrophage response to strains of the Mycobacterium genus

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    Mycobacterial infections are major causes of morbidity and mortality in cattle and are also potential zoonotic agents with implications for human health. Despite the implementation of comprehensive animal surveillance programs, many mycobacterial diseases have remained recalcitrant to eradication in several industrialized countries. Two major mycobacterial pathogens of cattle are Mycobacterium bovis and Mycobacterium avium subspecies paratuberculosis (MAP), the causative agents of bovine tuberculosis (BTB) and Johne's disease (JD), respectively. BTB is a chronic, granulomatous disease of the respiratory tract that is spread via aerosol transmission, while JD is a chronic granulomatous disease of the intestines that is transmitted via the fecal-oral route. Although these diseases exhibit differential tissue tropism and distinct complex etiologies, both M. bovis and MAP infect, reside, and replicate in host macrophages - the key host innate immune cell that encounters mycobacterial pathogens after initial exposure and mediates the subsequent immune response. The persistence of M. bovis and MAP in macrophages relies on a diverse series of immunomodulatory mechanisms, including the inhibition of phagosome maturation and apoptosis, generation of cytokine-induced necrosis enabling dissemination of infection through the host, local pathology, and ultimately shedding of the pathogen. Here, we review the bovine macrophage response to infection with M. bovis and MAP. In particular, we describe how recent advances in functional genomics are shedding light on the host macrophage-pathogen interactions that underlie different mycobacterial diseases. To illustrate this, we present new analyses of previously published bovine macrophage transcriptomics data following in vitro infection with virulent M. bovis, the attenuated vaccine strain M. bovis BCG, and MAP, and discuss our findings with respect to the differing etiologies of BTB and JD
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